Posted on June 16, 2009 by spcoll
[Part 5 of 5]
Following the discrediting of Meyer and Overton and the less than stellar debut of Pauling’s theory, anesthesiologists were again left without a central working theory of anesthesia. While Pauling still supported his own work, his fellow scientists remained uninterested and he gradually disappeared from the scene altogether.
Fortunately, the problem was not [...]
Filed under: Theory of Anesthesia | Tagged: anesthesia, knockin mice, Linus Pauling, Nicholas P. Frank, William R. Lieb | Leave a Comment »
Posted on June 11, 2009 by spcoll
[Part 4 of 5]
After nearly a decade of puzzling over the mechanisms of anesthesia, Pauling had finally developed a workable theory. By re-imagining molecular interactions, he had been able to produce an entirely new theory that not only explained the effects of general anesthesia but even demonstrated the reversibility of the process. In [...]
Filed under: Theory of Anesthesia | Tagged: Albert Schweitzer, anesthesia, Frank Catchpool, Linus Pauling, Stanley L. Miller, the stochastic method | Leave a Comment »
Posted on June 9, 2009 by spcoll
[Part 3 of 5]
Throughout his career, Linus Pauling’s inquisitive nature was widely recognized as a defining trait, second only to his legendary self-confidence. Indeed, it was his curiosity and analytical thinking style that made him the ideal problem solver. As a child, he spent his free time experimenting with pilfered chemicals, reading books on [...]
Filed under: Theory of Anesthesia | Tagged: alkylamonium hydrate crystals, anesthesia, Henry K. Beecher, hydrate microcrystal theory, Linus Pauling, Peter Pauling, xenon | Leave a Comment »
Posted on June 4, 2009 by spcoll
[Part 2 of 5]
In 1896, Hans Horst Meyer, a German pharmacologist and Director of the Pharmacological Institute at the University of Marburg, became interested in Ernst von Bibra’s theory of anesthesia. Meyer hypothesized that anesthetics were hydrophobic (repelled by water) and in turn attracted to other hydrophobic molecules. Lipids, the fatty molecules in brain [...]
Filed under: Theory of Anesthesia | Tagged: anesthesia, Charles Ernest Overton, Ernst von Bibra, Hans Horst Meyer, lipids, Meyer-Overton theory of anesthesia, University of Marburg | Leave a Comment »
Posted on June 2, 2009 by spcoll
[Part 1 of 5]
Anesthetics have been used throughout much of human history as tools for relieving pain and shielding the body. They have played a major role in human health and medicine from prehistory to the present. In our blog series “Linus Pauling: The Mystery of Anesthesia,” we will examine Linus Pauling’s [...]
Filed under: Theory of Anesthesia | Tagged: anesthesia, Ernst von Bibra, Friedrich Wilhelm Serturner, Joseph Priestley, Linus Pauling | Leave a Comment »
Posted on February 27, 2009 by spcoll
Cross-posted at Ether Wave Propaganda
Linus Pauling was born in Portland, Oregon on February 28, 1901, meaning that this coming Saturday will mark the 108th anniversary of his birth. (He died on August 19, 1994 at the age of 93)
Over the years, one of our annual habits around here has been to reflect back upon [...]
Filed under: Pauling-related Events | Tagged: Adolfo Perez Esquival, Albert Schweitzer, anesthesia, Belle Pauling, Betty Williams, birthday, Condon, George Wald, Herman Pauling, Linus Pauling, Maurice Huggins, Nicaragua, Oregon, Sidney Weinbau | Leave a Comment »
